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@cliffordfry

I stopped Prolia about two months ago and already feel new minor pains in spine. I know there is an increase in Spine fractures when quitting Prolia, but how much is this risk of increase? I am nearly 79 years old and have had one compression fracture back in 2005. I am not wanting another one. 🙂

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Replies to "I stopped Prolia about two months ago and already feel new minor pains in spine. I..."

There's a pretty high risk. You cannot just stop Prolia and expect your bone density to remain the same without some followup medication. Multiple studies have shown this. This is from one study:

"patients previously taking denosumab for two years who were then followed off medication had rapid drops in their bone density and a marked rise in their bone resorption markers that were well above baseline only 12 months after the last denosumab injection. Case reports then appeared of new, often multiple, vertebral fractures that developed in patients within a few months of stopping denosumab — termed 'rebound-associated' fractures. "

Your doctor said it was OK to just stop?? If so, he's wrong.

Don’t take the chance. I am talking from experience! Go on fosamex or something else

@cliffordfry If you know that the risk of increased fracturing occurs when stopping Prolia why are you stopping and just wondering about the odds. Take a follow up med to help block or reduce the rebound and do it right away.
Also you do not mention how many years on Prolia. The more years the greater the danger and the need for stronger drugs to try to block the rebound.
Even if you do not get the dreaded multi fracturing that can happen when stopping it you will lose all the bone you gained from taking Prolia in pretty short order.
You could consider spinal x rays if you want to see if you have the minor fracturing already occurring.

I stopped Prolia after about 6 shots and went on Boniva monthly, exercising, eating healthy etc. After a little over a year I have had 3 new compression fractures of the spine and my bones are very fragile. I am 67 years old! The rebound effect of stopping Prolia can be devastating so make sure you have a good plan for transitioning . I know now my PCP was not knowledgeable enough about the risks of stopping Prolia. You basically need to plan to be on it the rest of your life if you start.
I started Tymlos 4 days ago and I am praying it helps me build back some of the bone I have lost and I can go forward from here much more informed.
So many of us are just flying blind, trusting our medical professionals to lead us in the right direction….
This forum has been so helpful to me!