Hi Karla. Yes, I have tingling in my feet and some numbness. It is very bothersome when I am trying to go to sleep. I take two 500 hydroxyurea a day and twice a week I take three 500 hydroxyurea, and of course a daily 81 milligram aspirin. my platelets went up approximately two months ago. When this happened my doctor put me on three hydroxyurea twice a week. My platelets came down to 421 my last lab test. If my platelets stay down, I am hoping he will take me off of the three twice a week. I feel the tingling and numbness in my feet is due to the hydroxyurea.