Depends ehat you are taking re shortn as of breath. I have been on what is being called the big 3 for a couple of years and am on the highest dosages. The MAC is no longer getting better nor is it getting worse. So my infectious diseases doctor has also put my on Arikayce which I nebulise. At first it was every day until I couldn’t take it any more so my doctor let stay off it for a week and start again every second day. This was much better. However one of the myriad of side effects of this poison is it causes shortness of breath. Aftoer the first six weeks my sputum came back negative for MAC and it appears that is the way it is staying four months later. So I may finally have success and be off all meds in another month. Here is hoping I never catch this again. That is we’re acupuncture just may help.