I have been on low dose HU since 2022 for ET JAK2. I am currently taking 500 mg four days a week. I have lately been noticing leg aches but not shooting pains, I feel the best when I take 500 mg three days a week. The extra pill was requested by my hematologist to get my platelets to 400 (were about 520).
Best wishes, Eileen

I started gradually with HU, 500 mg, 1x week for a month, then increased over 6 months to 4x week. The adjustment has gone well. I also need daily iron for low iron but not anemic and daily baby aspirin. Could a lower dose of HU benefit you w/o side effects. Claritin is supposed to help with pain. Also, are you hydrating have your body weight? I find hydration is so important to my health and ET journey. Consult with your doctor first about Claritin and other changes to your plan. Also, are you seeing a hematologist/oncologist vs just your internist? They know more about MPN's over regular doctors. Wishing you brighter days in the future!
Karla

I also started on 1,000 mg per day in February of this year. I have really bad aches and pains. My legs are the worst. It is also worse at night. I haven’t said anything to my Oncologist but I will at my next appointment.