Hello
I have been on Sprycel since late 2018. Started at 100mg, I also had a roller coaster of BCR results which is fairly common from what I understand. Eventually reduced to 50mg, some side effects subsided and dealing with others. Edema and swelling would be one of them. I have had some significant swelling in my face and eye lids. I have been able to keep it under control after seeing other specialist. ENT, ophthalmology, and infectious disease. I have chosen to continue with the Sprycel simple because the benefits out way the alternative.
Hopefully you can find some way to manage side effects and keep working towards positive labs.