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← Return to Waldenström macroglobulinemia (WM): Anyone on zanubrutinib (Brukinsa)?
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Waldenström macroglobulinemia (WM): Anyone on zanubrutinib (Brukinsa)?
Blood Cancers & Disorders | Last Active: Sep 3 2:23am | Replies (33)Comment receiving replies
I am 75 and have been on Zanubrutinib since November 2023 … so nearly a year. I take 4-80mg capsules of Zanubrutinib per day and have experienced minimal side effects. My paraprotein levels, already high, have not increased since being on Zanubrutinib; however, those levels have not decreased any while being on Zanubrutinib. My cancer is stable is perhaps the most appropriate description.
Replies to "I am 75 and have been on Zanubrutinib since November 2023 … so nearly a year...."
Do you have a try other medical conditions- heart fib …?
I'm 68 years young and diagnosed with Waldenstrom's Macroglobulinemia 8 months ago. My oncologists/hematologists started me on Brukinsa (Zanubrutinib) at the time of diagnosis. Same dose as murray3 (4 capsules of 80 mg) daily.
I tolerate Brukinsa very well and it's helped my IgM value significantly. While still very high it's half what is was before Brukinsa.
Before diagnosis, my symptoms of WM were fatigue, rapid heart rate when doing physical tasks, fainting (with little warning), anemia and peripheral neuropathy. While rapid heart rate and fainting have (thankfully) subsided I still have low-moderate anemia and neuropathy (fingers & toes mostly). I received IV Iron once per week for 4-weeks which helped with anemia - the neuropathy is manageable (I use handwarmers - and heating pad for my feet) which helps with pain, numbness, tingling and cold in my extremities.
My Medical Team (UCSF & Sutter) feels good about the effectiveness of Brukinsa and my body's response - indeed I'm trending in the right direction 🙂
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What minimal side effects have you experienced?