Hi Steve, I was just diagnosis with ET yesterday after my bone marrow biopsy came back and also having the Jak2 gene mutation. I was just put on the Hydroxyurea as of yesterday and was wondering from you what are the side effects? I do feel some nausea and wondering about the dizziness and loss of hair? Has your wife gone thru any side effects? Also, I have severe numbness and tingling feeling below my knees (calves, ankles and feet are effected) by the ET not everyone has the loss of sensation but I have, so much so it has caused me to be out of work for 8 wks due to the fact that my job requirements are to be on my feet 8 hrs a day. I am 52 years old and never had any other disorder so this was a shock for me as I'm sure for your wife as well. I should mention I have had every blood test imaginable and my platelet levels are extremely high, red and white are normal.