1. < Polymyalgia Rheumatica (PMR)

Rapamycin for Polymyalgia Rheumatica?

Posted by menetski4 @menetski4, Oct 9 5:59pm

Has anyone had experience using Rapamycin for PMR?

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megz | @megz | Oct 9 6:50pm

How do you hope Rapamycin might help with PMR? I only found a couple of small scale experiments with Rapamycin/Sirolimus for arthritis and the results are confusing. Small improvements in arthritis symptoms while taking Sirolimus included a decrease in methotrexate and other steroid sparing drugs but a small increase in prednisone dose. On the other hand, the control group made a steady reduction in prednisone dose. If you have any studies of its effectiveness in PMR treatment, I'd be interested to see them.

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menetski4 | @menetski4 | Oct 10 7:18am
In reply to @megz "How do you hope Rapamycin might help with PMR? I only found a couple of small..." + (show)
@megz

How do you hope Rapamycin might help with PMR? I only found a couple of small scale experiments with Rapamycin/Sirolimus for arthritis and the results are confusing. Small improvements in arthritis symptoms while taking Sirolimus included a decrease in methotrexate and other steroid sparing drugs but a small increase in prednisone dose. On the other hand, the control group made a steady reduction in prednisone dose. If you have any studies of its effectiveness in PMR treatment, I'd be interested to see them.

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I was hoping someone might have tried rapamycin as a down-regulator to help decrease/discontinue the need for prednisone. No one knows the cause of PMR. I bet there are other old drugs which can be repurposed as treatment.

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