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Evenity Advice?
I am 66 years old and have been on Reclast for two years with some improvement in my scores, although the second year my spine score went down. My endocrinologist at Mayo Clinic discussed Evenity and Tymlos and I think I am going to try Evenity since it is one year and convenient to go once a month to the clinic to get the injections. I had concerns about the black box warnings regarding heart attack and stroke, but she reassured me that she has not heard of anyone experiencing this. I also have an appointment with my cardiologist to see what he says before I start. I don’t know what else to do and yes, I’m very nervous about taking this drug, but I know it’s supposed to give me big gains in my spine where I need it the most. Any additional advice?
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@awfultruth the problem is that research hasn't caught up with this idea. My doctors didn't even want me to do Evenity after Tymlos at all- just Reclast- and McCormick didn't suggest it either. Doing more than one year of Evenity has not been studied either. I am not afraid of cardiovascular effects but sclerostin has functions throughout the body.
This is moot for me because with GERD/reflux I cannot take risendronate or alendronate. McCormick did tell me risendronate is the weakest bisphosphonate (so should not be used after Prolia).
Tymlos isn't approved for a second year either. I only did 4 months Evenity so I still have 8 more to go. So another idea that has been mentioned in articles is to do short bursts of Evenity since the first months are the most bone-building. I could do 4 months again, two times. But will my doctor okay that/ Research is ongoing. He tends to wait for results. Good luck with negotiating and let us know!
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1 ReactionMy endocrinologist wants me to start on prolia after my endocrinologist of Evenity holiday. I don't want to do this and suggested alendronate. He is against this because I was in alendronate for 5 years prior to evenity. I am wondering about risendronate instead. What about one course of prolia then back on Evenity. Ugh!!!! I absolutely hate this so stressful. Any ideas are most welcome. I took forteo prior to alendronate
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1 Reaction@windyshores you mentioned Tymlos isn’t approved for a 2nd year…that’s the maximum amount of time. Weren’t you on Tymlos before Evenity? And why were you limited?
@gravity3 sorry for your complicated situation. I don't know your history other than what you just stated. Current and prior DXA's, any fractures, your age, reactions to previous osteo meds if any, and a timeline of what you did when and the result. Any comments I would make would just be suggestions of possibilities. Of course others would likely chip in.
What you are facing is what all of us taking osteo meds are facing or will be facing. That is none of these meds leads to a solution where you don't have to keep doing something else. You cannot safely take the bisphosphonates forever, some seem to think you can take Prolia forever but if you ever have to stop woe is you and the anabolics are for short term gain and something else has to be done to keep what you gained.
One question, what did you mean by an Evenity holiday?
@dooshie sorry I meant a second course. It is taken for two years 🙂
Alendronate
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3 ReactionsJust finished 1 yr of Evenity and will start prolia next if I don't negotiate a new plan with my endocrinologist. I am 76, just starting hrt again after many years without... estrogen, testosterone and progesterone.
I intend to talk with my endocrinologist about this possibility....one or two injections of prolia and then back to evenity or tymlos???? I have already had two years on forteo.
@gravity3 Tymlos after Prolia might be risky in terms of rebound and various resources (McCormick, Leder) say it also isn't effective.
You or someone else shared a study on Evenity in that situation and it did seem to counter rebound and had was effective though effeciveness was reduced by prior Prolia.
Are you avoiding a bisphosphonate?
I was on alendronate for five years prior to evenity. A bisphosphonate would be my choice but my endocrinologist is against it. Ugh! I feel helpless.
To be honest, if your endo suggests Tymlos after Prolia I would get another endo!
I forgot you did Evenity after Tymlos (like me). To get more time on treatment I wonder if you could do one injection of Prolia then Evenity then bisphosphonate (Not medical advice here, just wondering). It seems as if you will have to be on a bisphosphonate at some point but extending the time on treatment is what we all want if we have serious osteoporosis.
I was just watching a video on Osteoboston with Dr. Wein (?) and the risk for jaw necrosis and atypical femur fracture might still be low if you did another year. Check with pharmacist or doctor?
This is what really gets me. Noone knows how to keep us okay long term!