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@dortbarb

I’ve been taking Verzenio with an aromatase inhibitor (first Anastrazole, now exemestane) for almost a year. I do not have MBC, but my doctor recommended Verzenio because of my lymph node involvement (four positive noses). The only side effect I’ve noticed is low white blood cell count. This caused me to stop taking Verzenio on two occasions. I resumed taking it after one to two weeks off. Because of this tendency I get frequent blood tests. Unless this side effect gets worse, I intend to continue taking Verzenio for the recommended two year period. I need to add that the body aches and stiffness caused by aromatase inhibitors are still present, but tolerable.

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Replies to "I’ve been taking Verzenio with an aromatase inhibitor (first Anastrazole, now exemestane) for almost a year...."

Youll get the body aches from exemestane because its half life is about 50 hours.
That means you take tge pill Monday, youve got a full dose. Take it Tuesday, youve gotv1/2 Mondays a full dose of Tuesdays. Now youve got more than the original dose in your system.
If youve been on it more than a year, ask your dr if you can take it every other day or take a 2-4 week break.

But are you sure its not the Verzenio? Did you have any initial side effects with that? Diarrhea?