Yes, HU lowers platelets. Mine went from a high of 800s to the 400s. It took two years to get them there, but that's where they'venstayed x 5 years. I sometimes spike up past 500, but they always go down again at next test. Hemo calls this "very stable." I do have the CALR mutation, so I am at slightly lower clot risk than JAK2 folks. I am 70 yo.

Ditto Jane's and Lori's posts!

Best on the knee looky loo.