I just had a bone marrow biopsy done three days ago with only an anti anxiety medication given, a small dose I requested to take the edge off. My doctor was very quick and numbed me up very well, explained everything as he was preforming the procedure and let me know when the moments would be when I would feel more pressure and some pain. Not sure if being a retired Oncology nurse, who has been around this before made it better or worse. I was glad I had the Lorazepam on board prior for sure. It wasn't as bad as I thought it would be. I am definitely emotionally fragile at this point as I have just gotten diagnosed. My advise is advocate for yourself because you know what you need. There is no reason to suffer emotionally or physically. In my case I was more worried about my emotional reaction as I am prone to anxiety. If this biopsy didn't go as well as it did I would request sedation for the next one or if I felt I just couldn't handle it at that time given my status.