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Gleason7(3+4) - treatment options recommendation

Prostate Cancer | Last Active: Oct 7 1:02pm | Replies (237)

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@chipe

Just went back to the pathology report. I am a T3B. But the only Gleason score I can see on it is a 7. Here is the summary:
Synoptic Report
:
Specimen
Procedure: Radical prostatectomy
Tumor
Histologic Type: Acinar adenocarcinoma, conventional (usual)
Histologic Grade
Histologic Grade
Gleason Pattern: Gleason Pattern
Primary Gleason Pattern: Pattern 3: 50 %
Secondary Gleason Pattern: Pattern 4: 30 %
Tertiary Gleason Pattern: Pattern 5: 20 %
Grade: Grade group 2 (Gleason Score 3 + 4 = 7)
Intraductal Carcinoma (IDC): Not identified
Cribriform Glands: Present
Treatment Effect: No known presurgical therapy
Tumor Quantitation
Estimated Percentage of Prostate Involved by Tumor: 41 - 50%
Extraprostatic Extension (EPE): Present, nonfocal
Location of Extraprostatic Extension: Left posterior
Urinary Bladder Neck Invasion: Not identified
Seminal Vesicle Invasion: Present, bilateral
Lymphatic and / or Vascular Invasion: Present
Perineural Invasion: Present
Margins
Margin Status: Invasive carcinoma present at margin
L
inear Length of Margin(s) Involved by Carcinoma: Less than 3 mm (limited)
Focality of Margin Involvement: Unifocal
Margin(s) Involved by Invasive Carcinoma: Left seminal vesicle surgical
margin.
Margin Involvement by Invasive Carcinoma in Area of Extraprostatic
Extension (EPE): Not identified
Gleason Pattern at Margin(s) Involved by Carcinoma: Pattern 3
Regional Lymph Nodes
Regional Lymph Node Status: Tumor present in regional lymph node(s)
Number of Lymph Nodes with Tumor: 1
Number of Lymph Nodes Examined: 13
pTNM Classification (AJCC 8th Edition)
pT Category: pT3b
pN Category: pN1
Best Tumor Blocks for Future Studies
Tumor Block(s): F14
Normal Block(s): N/A

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Replies to "Just went back to the pathology report. I am a T3B. But the only Gleason score..."

Perhaps getting a second opinion on your surgical pathology would be helpful to nail down your gleason score. 20% is a lot of tertiary pattern 5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382533/

You said “ My Gleason was a couple of 9's and a couple of 7's.”. It sounds like your tertiary 20% of 5’s was showing up in the biopsy as some 4+5 but mostly 3+4. Margins also had involvement, along with a lymph node and seminal vesicles.

As @farmanerd says, get a 2nd opinion.

With all the issues in this report you sure should get a second opinion, I can’t imagine a GU Oncologist would not recommend you be on ADT.

You don’t want this to come back in a short time you really need to be more proactive. Your life is really dependent on top notch medical care.