I have ME/CFR too and exercise can be too much. I'm now in the later stages of both so I'm mainly in fight or flight mode. But you asked about medications so here goes:

Please note, if you are afraid of taking medications, these might not be for you.
LDN is supposed to be good, mentioned above. I'm having a hard time finding here in NJ. Also it has to be compounded and my insurance doesn't cover it.
Most physicians use antidepressants, Elavil is an antidepressant. The ones used most are TCA's. I found them too sedating and made me groggy. They helped with sleep though, I have to admit.
Sleep is crucial in both syndromes. I went to a sleep doctor and found my deep sleep, where your body repairs itself, was being interrupted all night so my body couldn't repair itself from the day's activities. He started me out with over the counter melatonin. When that didn't work, we tried the TCA's mentioned above but as I noted, they left me groggy with a drug " hangover". Finally, we dived into sleep meds like Lunesta and Ambien. I've been on Ambien way beyond it's temporary usage recommended. I haven't had any side effects. It changed my sleep, therefore my life forever. Please find a sleep doctor or have your PC order a sleep study.

To increase energy and not be fatigued, try Provigil ( generic modafinal ).

The heaviest hitters were the opiods, not recommended of course but I'm not an addict, carefully monitored by myself and my pain management doctor.

Please note: I am in the severe category so for mild or moderate symptoms use the beginning meds. I listed them in order on purpose from mild to severe interventions.

I hope this helps. I'm 21 years into this journey. Of course I've done holistic, acupuncture works, OT great, support systems essential. Again, you asked specifically about meds so that's what I focused on. Good luck with your journey! 21 years ago there was no knowledge and no support. We were ridiculed, gaslighted, sent to psychiatrists etc. I survived though I lost family, friends, and my good looks ( lol). Check out support groups. I'm a social worker who believes they are best. We are warriors!

"Heavy" hitters inc