Hi @teachpeace I have Waldenström's for 2 1/2 years getting regular infusions but my neuropathy kept getting worse, so my oncologist put me on zanubrutinib as well. three months now and my neuropathy is finally getting better - I can curl my toes again!. My side effects are fatigue and bleeding under the skin of my arm - looks like a bad bruise. I am sorry your father is getting a worse reaction. I did get an anti-nausea pills in my mix that I need sometimes. I am very happy with my progress but will be happy to get off the meds.