Good morning lindagualtieri. I am from Kentucky. I have had Polycythemia Vera (PV) for 6 years (age 65 now). A routine blood test showed my platelets at about 600. Yes, I too have the genetic mutation of the JAK2 (V617F). I am still waiting for genetic mutation superpowers like spiderman but nothing yet. I am taking 500 Hydro (HU) once a day. My platelets are in the 300 range which is normal depending on what blood expert you talk to. Other than fatigue and brain fog late in the afternoon, I have very few symptoms. I believe physical exercise is important. I go to my gymnasium 2 to 3 times a week and feel much better because of it. I am active in my veteran organizations. Most people I know have no idea I have the diet coke of cancers called PV. I have an occasional drink when watching my Liberty University play football and have had no complications because of it. I refuse to give up on the activities I enjoy because for some unknow reason my body decided to mutate. Hang in there and stay frosty. You are not alone. J.