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Weaning off of Pristiq

Depression & Anxiety | Last Active: Oct 5, 2025 | Replies (67)

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I recently started pristiq the 1st of August
they started me on 25mg about a month ago. Then she recently put me on 50mg a week ago But it’s making me very irritable so I am going back to 25mg today for a week and then I will start Zoloft. Do you think the withdrawals will be horrible?

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Replies to "I recently started pristiq the 1st of August they started me on 25mg about a month..."

Hi all.
I've just started weaning off 100mg Pristiq which I've been on for 5 years. Reasons for weaning off ate weight gain
and mainly emotional numbness which has caused me to no longer feel motivated, passionate, loving and creative. After reading all the posts here I have decided to take one dose every second day for a couple of weeks, then every third day for a couple of weeks and lastly every 4th day then just stop. So far I haven't had any withdrawal symptoms. I will keep you posted on how I go. All the best all who are trying to get off this awful drug.

Please consult your doctor- a slow taper is highly recommended.