I have no trouble with occasional spicy food. I don't drink alcohol, but your pharmacist can often answer these types of questions. My mom had many questions about her meds after open heart surgery, and the guy at Walgreen's knew more about her meds than the hospital nurses. Some big hospitals have an "ask a pharmacist" or "ask a nurse" line.

I have PV and take Hydroxyurea. My oncologist said I can have alcohol in moderation. I drink a few glasses of wine now and then and even Vodka cocktails with no issues or side effects. I’m taking this drug for almost Two years now. It’ll take a few months to get the dosage correct so hang on until your numbers stabilize. Good luck!

Hola, yo bebo una copa o dos de alcohol los fines de semana.
No he tenido ningún problema.

I've never heard of any limitation on alchohol (except moderation) or spicy foods, but it would make sense to me to take the Hydroxyurea in the morning with plenty of water instead of in the evening, to avoid any stomach upset.