Hello all. I am beginning Xtandi (120 mg/d) today in addition to Orgovyx (120mg/d). I've been taking the Orgovyx about 9am (give or take) and have thought to take the Xtandi an hour or so before bed (so on or about 8:30/9pm. I'm on these two drugs till Nov 6 when I have a CT scan. At that time I think we'll be talking radiation. I am 77, Gleason 4+3, intermediate cancer, PET scan indicates tumor (aggressive) is confined to prostate. Any sharing or insight is really welcome. Five months ago none of this was on the table and I still have no symptoms. I've always enjoyed pretty good health. Thanks again.