Alendronate Inactive Ingredients

Posted by aacatsaregreat @aacatsaregreat, Sep 7 3:33pm

When I began taking Alendronate my prescription label was Marlex Pharma. The refill I picked up this week is from Exelan Pharma. I was curious if there was any difference in the medication and found that the Exelan brand lists mannitol as an inactive ingredient while the Marlex brand does not.

Is it possible that different inactive ingredients in one might promote side effects that didn't occur with use of the other? There seem to be quite a few Pharma companies providing Alendronate. Has anyone had side effects with any specific brand name?

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Not much help but, some are allergic to mannitol.

REPLY

I believe I have an allergy to mannitol which caused diarrhea for me. The change in my aledronate manufacturer was the only change in my life at that time. Many pharmas use mannitol as an inactive ingredient. I was able to return to my original formulation.

REPLY
@gently

Not much help but, some are allergic to mannitol.

Jump to this post

Thanks for your reply! Yes, I'd read that some are allergic to mannitol. I would guess that any medication contains ingredients that might cause allergic reactions. It's something to consider and to know about if something out of the ordinary occurs.

REPLY
@maggieb892

I believe I have an allergy to mannitol which caused diarrhea for me. The change in my aledronate manufacturer was the only change in my life at that time. Many pharmas use mannitol as an inactive ingredient. I was able to return to my original formulation.

Jump to this post

Thanks for the response! That's good to know (not the diarrhea, I'm sorry to hear that!). It gives me something to be aware of when I take the different pharma refill in a few days. It seems various manufacturers of any med often use some different "inactive" ingredients in their products so as not to infringe on the patented contents of the brand name medication.

REPLY

I am taking alendronate and the diarrhea is awful. I am trying to learn as much as I can before going back to the doctor. Thanks to everyone for all of your input.

REPLY
@jbones

I am taking alendronate and the diarrhea is awful. I am trying to learn as much as I can before going back to the doctor. Thanks to everyone for all of your input.

Jump to this post

How long have you been taking alendronate and what dose? Thanks.

REPLY
@jbones

I am taking alendronate and the diarrhea is awful. I am trying to learn as much as I can before going back to the doctor. Thanks to everyone for all of your input.

Jump to this post

Diarrhea is listed as one of the possible side effects of alendronate. How long have you been taking it and how long does the diarrhea last? The information that comes with my prescription says to check with your doctor with any side effects that are troublesome or that don't go away. Either way, it might be a good idea to get some feedback from your doctor.

I hope things get better for you!

REPLY

I have been taking alendronate for almost a year. The diarrhea usually lasts 3 to 4 days. I will talk with the doctor about this condition. Thanks so much.

REPLY

In reference to my original post -- I've suffered no side effects after receiving the Exelan Pharma brand alendronate (rather than the Marlex brand I was originally given) that lists mannitol as an inactive ingredient.

REPLY
Please sign in or register to post a reply.