I have been on tikosyn 250 mg. since September 2023. I am 80 years old and was in persistent Afib for six months with no relief from rate medications, which caused a great deal of fatigue. I have now been in sinus rhythm with no issues for a year and am hoping medication continues to work. I did have headaches for a short time after starting tikosyn but those didn't last long. I hope you find the solution to your side effects or a solution to your Afib. It's not fun.