Not sure if this is where I reply to all. Thank you! I have the MTHFR mutation, most of us do. I was supplementing with a professional nutritionist and obviously taking way too much. My B12 was great, however all of the other B vitamins and folate were off, B6 being the worst. I have not been diagnosed with neuropathy as of yet, however, it seems clear to me. I stopped the supplements and will be mindful of the food ( salmon, avocados, ... all of the things I eat have high levels. I will read the discussion posted. I experience night sweats and have lots of hair loss. It has been very challenging, with lack of sleep!