Hi Sharon, @sharonsturdivan, welcome. These decisions are tough. I'm facing a surgical decision, unrelated to my lung cancer, and I'm finding that I come up with new questions every day. I try to weed through those looking for the ones that are most important based on where I'm at in this process, and I pass those along to my doctor or nurse. My team has been receptive and are responsive to those. Do you feel that your questions to your doctors have been answered? Have they given you an idea of how well your kidneys may tolerate the chemo and/or immunotherapy, especially an aggressive dose? Cancer meds in general can be hard of our kidneys and liver. My targeted therapy causes my liver and kidney numbers to go up any down. Lots of water helps, but it can only do so much.