I have had multiple bone marrow biopsies. I have only used local anesthetic, which has worked well for me. Usually, I have other scans or tests after the biopsy, so I have not asked for sedation. I walk for a day or so like I just got off a horse - but otherwise, I am lucky to feel OK.

Counting down the time helps when getting the biopsy. I learned this from the person at Mayo who was doing the biopsy. He would count down the number of seconds each time the needle was inserted. It kept me focused on the countdown—a great distraction!