So sorry your wife and you are dealing with this. I was diagnosed with ESS stage 4b in 2018. I had the radical surgery and then started hormone AI. Lots of side effects for me. Bone and joint pain, nausea, extreme fatigue and more. The best advice I can give is for her to do the research on nutrition and decide what lifestyle changes she can make. The lifestyle changes in sleep, diet and exercise really do make it easier to deal with this. Also, as someone who has a very supportive and loving husband, knowing that you are not in this alone is huge. Good luck and sending you positive energy.