I take Gabapentin, and have no side effects, or trouble, from it. I take Tylenol at the max, every day of my life for years. I take cyclobenzaprine (flexeril) 3 times a day, religiously. I've gone off the Flexeril a couple times because I just plain ran out while travelling for months all across the US. It's not withdrawal I am concerned about. My left leg literally twists up, and my foot turns in, from the pain and cramping, until I get another cyclobenzaprine prescription. I am eternally grateful that I can take it. The other choices didn't work for me, though they work for others sometimes. I was told to take magnesium to replace the flexeril, but my IBS couldn't take it. I'd spent all my time in the bathroom, which really doesn't work when travelling. It's not fun if you stay at home, either. But I've heard of magnesium gel, a topical, and that I do need to try out. As for Cymbalta, I've had this disease now since 1990. And it was misdiagnosed for decades. So, it's only in the last few weeks I'm trying Cymbalta. I discovered only after starting it that people say it's a pain to come back off of. Lots of drugs are hard to come back off of. Not least of all because of possible "withdrawal" symptoms. I had to go off of St. John's Wort to try out Cymbalta. That wasn't fun either. Not because of withdrawal, but because the St. John's helped with the natural feeling of hopelessness that we who are treated like this, have to fight off most days. I've had a year of hydrocodone twice during all those years. One year of Zanax. All of those were "a pain" to quit when the doctors exhausted their meager ideas to fight what I live with 24/7, ever since 1990. Withdrawal, if necessary to find solutions my doctors can live with, at the same time it works for me, is minor. I think the only time I'd be concerned is if going off something gave me seizures, or real dehydration. Perhaps you'd like the St John's Wort. I started it because there's evidence of a brain-gut connection and I was hoping it would help my GI tract. I can't take most antidepressants and it was risky in the first place for me to even try out Cymbalta. If it works, why would I ever want to go off it? To me, it's the same as some people's major injuries to spine, where they will be on an opioid the rest of their lives, and grateful for it.