I am sorry he has developed ascites.

After a stage 2 diagnosis at Mayo, followed by 12 Folfirinox cycles, with checks at Mayo every two months showing some improvement, and then five weeks of radiation - all in advance of a scheduled Whipple surgery at Mayo, my sister, age 64, developed ascites. She had weakened progressively over this time.

Given ascites the surgeon said they could not operate, and that if able, she should return home for additional chemo, but she was hospitalized following the next session, then stayed in rehab for two weeks during which there was continuing metastasis to her peritoneum and possibly lungs, until she returned home for hospice care. She passed two months later.

Here is a reasonable, but specific, resource on pancreatic cancer and ascites. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060830/.

At the last visit to Mayo there was some indication from scans of limited peritoneal nodules. She returned home and underwent five weeks of radiation. Her CA-19 was beginning to increase from her lowest active chemo level of 43.

About two weeks into the radiation, she began to show signs of ascites.

I travelled back and forth those times to Mayo, and assisted over the six months of chemo. I tried daily to convince her to relocate to Rochester, but she felt being with her cats at home was more important. My continuing belief is that anyone with this disease should relocate to be close to a center of excellence - the oncology care is better, the testing methodologies are better, and the staff is better. Rochester is a nice town, and various housing is available within walking distance of the center.

The radiation treatment was part of the process for the Mayo doctor to perform the Whipple.

I didn't mention it, but she had two paracentesis with cytology - the first shortly after the ascites was noted and it was negative. The second a month of so later was positive. Later, during the two weeks in a recovery facility, she was checked and found metastasis to lungs. Here's another link for review: https://jamanetwork.com/journals/jamaoncology/fullarticle/2757397

She had to be drained, sometimes daily as the ascites became more pronounced - this started after she crashed and was hospitalized from the attempted chemo restart. I probably have some of the chronology wrong - here is the link to her story. https://connect.mayoclinic.org/discussion/my-sisters-battle-with-pdac/

I'm sorry - this is still difficult. I try to review Connect to provide what little bit I know about this horrible disease.

I appreciate you sharing information to myself and others in this journey. I hope you find comfort in knowing you did so much to help your sister.
My husband is supposed to start Folfirinox in a couple of weeks, after being off of Gemcitabine/Abraxane for over a month since it appears to have stopped working. After reading what your sister went through when she restarted chemo now has me very worried for him. Unfortunately, restarting chemo is his only option other than palliative care.

Thank you, this is good information. I’m glad to hear palliative care provides so much and has been beneficial to your care. I will definitely pursue this option and find a palliative MD.

My husband ( stage 4, mets to liver) developed bloody ascites just one week before he passed away. He was treated with fulfirinox, then gemcitabine and since going for third line had entered a Ph1/2 immunotherapy study the week prior to his passing. While hospitalized they tapped him 3 times ( MWF) before he passed on Sun. Does anyone have knowledge of immunotherapy treatment and bloody ascites?
Thank you you any feedback.