I started imbruvica on Oct 4, 2017. I had rituxan infusions, 2 sets of 4, in 2016 because of symptoms of spleen ischemia (I also had lymphoma symptoms, including night sweats and frequent bacterial infections until late in 2016). My lymphocyte count dropped below 2K at one point and was at 10K when I started imbruvica because of worsening lymphoma symptoms. At two weeks after starting imbruvica my lymphocyte count had risen to 20K and to 30K 6 weeks after starting imbruvica. There was notable reduction in palpable lymph node sizes at both the first and second check ups, and milder and less frequent night sweat (which I note on my calendar). I am taking only 2 capsules daily. I had a transient localized allergic rash soon after starting imbruvica that might have been caused by Imbruvica. But otherwise, no apparent side effect, e.g., no bleeding problems.