My neuropathy hit me almost all at once. I was just laying on the couch when, out of the blue, both of my feet and lower legs got tingly and numb up to my knees. A couple of days later (as I recall) I started getting internal body tremors. My feet were almost entirely numb for months even after I stopped the B6 supplements. For some of us it gets stored in our tissues and is very hard to get out.