I have been diagnosed with CCUS, too. I don't really know anything about how genes are affected, and I'm not sure knowing would change anything. I've had low blood platelets since 2014; however, no one caught it until years later (and I have a physical every year). I'm now going, once a year, to Dana Farber in Boston, and I guess with some recent gene changes, they now call it CCUS. I feel like it's a matter of time before I get MDS or worse. I want to connect with others to see how they are doing and see what if any, symptoms you have. I have very low blood platelets and am constantly exhausted.