How high has anyone seen Lambda free light chain go with Mgus?

Hoping for the best for us tomorrow .. I have my bone biopsy too…
My Lambda is over 1200 and don’t know what that means yet ..
Keep us posted.. thx

God be with us
Prayers for everyone with any cancer

I don't understand your lambda 1200 vs mine 45.7
I think there more concerned about the M spike & the protein electrophoresis

All the best for you both!
Keeping our fingers crossed.
Mascot

@sammiemuss and @sallik74
Here’s hoping that today’s bone marrow biopsies are painless and quick for both of you. Be sure and ask lots of questions. Your hematologist/oncologist would be able to give you more definitive information after the results come in from your bone biopsy. Make sure that you get a promise from them that they will call you, or schedule an in office or telemedicine appointment to go over the results of your biopsy. If you didn’t do this while you were there, you can always call and schedule that appointment.
There are many things to consider such as pre-existing conditions, and any symptoms that you may have as well as the results of your bloodwork and biopsy. You will want this to be a conversation with your physician. We are all very different in the way that we present. Speaking only for myself, I rarely look at my chart to get the results of my bloodwork or testing ahead of the discussion with my doctor. It increases my anxiety, and then I start feeling symptomatic when I actually am not. The mind-body connection is the real deal.
Fingers crossed for a good experience for both of you.

That's truly a set of Q for your medical team? I would put those in a message in patient portal if available and expect a better explanation in a few days to a week (they usually have a disclaimer that they have X days to respond).
Ask them gor further patient education resources as well.
That's been my frustration with my husband's heme-onc team. As a former research lab tech, I can and do read medical journal articles and try to advocate on his behalf but it's a bit of a struggle. MGUS can just linger or "smoulder" for years, with a wide range of overall symptoms but no singular treatment option(s). Healthy diet, exercise as tolerated, is generally the advice he's been given

Kappa Lambda is usually a ratio. You should be able to check this against your separate kappa and Lambda readings. (Kappa and Lambda are both letters of the greek alphabet. Everything has to have a name)!

The M spike could be your igM elevation, but there are other possibilities too. These are really fair questions to ask your medical team. It's about you and you are entitled to know.

Your readings alone may be a bit excessive but don't look too bad (My own are vastly higher and I still have no apparent health issues) but everyone is different and there must be some reason for you to be having a bone marrow biopsy.

Thank you !
Biopsy went well
Still have questions on the blood results
I don't see a message portal to ask questions
I'll look again

Yes mine biopsy went well too .. I worried so much and it was easy with taken comfort sedation .. I'm very please , now the hard part to wait for results ..
Thx for everyone’s kind words . ❤️

MGUS is a condition that involves an abnormal protein produced in the bone marrow by plasma cells, the cells that produce antibodies (immunoglobulins) like those that protect you from infection or are stimulated by vaccines. The various proteins are segments of the antibody and are named to identify them. Some are considered heavy chains and some light chains. The abnormal protein produces a spike called an M spike on a blood test called serum protein electrophoresis. An M spike is normally not present and when it is, it is identified as to what piece of the antibody is in excess, eg. kappa or lambda light chain. MGUS most often remains stable with fluctuations in levels up and down over years. It typically produces no symptoms but can rarely progress to a bone marrow (blood)cancer called Multiple Myeloma. Because of this, people with MGUS have periodic blood monitoring (every few months), to “watch” the levels. If it does ever progress, treatment can be initiated at an early stage. A bone marrow biopsy is done to determine the % of plasma cells and check for any other abnormalities in blood cell production of red, white and platelet cells.
This is a very complex area of medicine, but it helps to understand what is happening with your body and why these tests are recommended.