@sandrac The scariest issue with Prolia is when stopping it. I have not followed this thread so maybe you are well aware of that but for anyone that might not be, it's when stopping Prolia that it gets really scary. You lose bone rapidly and some people have multiple fragility spinal fractures. And by multiple I have seen 8 or 10 fractures claimed after stopping Prolia without a strong bio-phosphonate to counter what happens when stopping. Apparently the longer you are on Prolia the greater the risk of the multiple fractures.