What is the recommended treatment after 6 Pluvicto doses?

Completed Pluvicto #6 July 16 and am happy to hear the
possibility of additional treatments if needed. PET scan Sept 04 then a sit down with my Doctors to decide next move.

Lupron and Nubeqa for me. They mentioned something about 2 years of it. I’ll find out more when I go back in September And have my scan.. I completed my 6th.dose in April. I went straight from chemotherapy to Pluvicto so I was already on the two drugs mentioned above when I started pluvicto.

Larke posted above that it is at UPenn Medicine.

The FDA has only approved six treatments of Pluvicto, so that is all men can receive in the US. A few US sites are doing clinical trials of extra Pluvicto infusions. (I learned on Wednesday, August 14, that Mayo Rochester is not one of them. We asked during an appointment with Dr. Kwon, and got the same answer later that day from the Nuclear Medicine providers giving my husband his sixth Pluvicto infusion.)

I finished 6 rounds of the original clinical trial Lu177 PSMA-617 in 2022 with remarkable results. It was approved in the US a few months later as Pluvicto. Now, I will be one of the first patients to repeat the same 6 treatments, starting Sept. 3, 2024. Going into unknown territory, again. Beats dying without trying.

Dear smc24,
Where are you having another six Pluvicto treatments starting next week? I apologize if you posted that information somewhere and I missed it.

Simon Cancer Center, Indiana University Health Indianapolis will be administering this second and unprecedented round of treatments starting early September 2024. I was one of the original clinical trial patients at the University of Chicago in 2021-22. My response was miraculous. It was identified as PMSA 617 Lu177 which has now been approved in the US under the name Pluvicto. I was given just a few months to live with extensive stage 4 metastatic prostate cancer just prior to starting. It has now been more than 2 years before tumors were growing again and PSA rose. The IUH and U of C oncologists knew each other. The repeat is essentially considered another trial, although not a formal trial, as we find no patient data on repeating the treatment.
Other options were considered, but this seems to be the best for me. I've had most all standard protocol treatments, and more for 10 years.

Thanks so much, smc24. My husband's medical oncologist is at Simon in Indianapolis, though my husband chose to have his Pluvicto treatments at Mayo Rochester instead, over my objections. (I objected because we live about an hour from Simon and ten-plus hours by car from Rochester.) My husband just finished his sixth Pluvicto on August 14, whereas you finished what is now known as Pluvicto in the original clinical trial years ago, and I suppose that might make a difference in whether my husband would be considered for another round any time soon. He has a scan on September 25 to show how effective Pluvicto has been against his many metastases.

My first round costs were covered by the pharmaceutical company in the trial. No insurance involved. Now. Medicare and my supplemental insurer will pay.
The two year period between the end of the first round and the start of the repeat treatments was a definate factor in my medical staff's decision to move forward with this treatment. FYI, I had ARC targeted beam radiation on a few problematic tumors this spring prior to this decision. It helped, but just kicked the can down the road a little more.
Stay in touch.

Thanks so much once again, smc24. My husband also had some spot radiation and then an ablation to a spot on his spine before starting Pluvicto. As you say, it just kicked the can down the road. His next appointment with his medical oncologist at Simon is late October. I may try to contact him before that, depending on what the September 25 scan shows. I will definitely keep you posted.