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Prolia and its side effects.

Osteoporosis & Bone Health | Last Active: Aug 20 10:39pm | Replies (69)

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@mayblin

Thank you very much @windyshores for the overview! I'd like to point out a few things from my readings and welcome any input from any members. Evenity - it's a beast in building bones in a quick manner. The saying that it's anabolic during first few months and antiresorptive in second 6mo doesn't hold entirely true to me. If you look at btms changes during 12mo evenity treatment, the decrease in CTX is greatest at 14days to 1month, so is increase in P1NP. This tells us it is antiresorptive from the very start, just its anabolic effect overpowers its antiresorptive effect during early months of treatment. For first 0-3 and 3-6mo, the bmd% increase were comparable, but for second 6mo period, bmd increase continued although to much lesser degree (approximately 40% compared to 1st 6 mo) according to some studies, still very impressive. I also read that men and women retain bone mass differently after anabolic treatment - men retain much better. This might be the very reason (of course among other things such as lifestyle) Mccormick just needed a period treatment of fosamax after the completion of Forteo, while most of us go on a drug to another and another. If it were up to me and cost isn't an issue, I'd use antiresorptives as a replay tool not a mean to maintain bone density and its architecture. Of course it's easier said than done.

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Replies to "Thank you very much @windyshores for the overview! I'd like to point out a few things..."

@mayblin the chart on Ben Leder's video does show lower CTX in the first months, going up gradually, but it also shows a P!NP going way up and then quickly going back down, within a month. My doctor told me they don't really understand how Evenity works (!) because for most of the course, including the last 6 months, it is actually a weak anti-resorptive.

It is probably more accurate to say that Evenity is primarily anabolic for the first months. I have seen 0-2, 0-3, 0-5 and 0-6! So who knows! And the CTX is lower in the beginning but is the dominant effect in the last 6 months. It is an oversimplification to say it is anabolic the first half and anti-resorptive the second half so thanks for pointing that out. That oversimplification is repeated a lot in resources for us lay folks.