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What is the recommended treatment after 6 Pluvicto doses?

Posted by donalan @donalan, Mar 13, 2023

I will have had 6 Pluvicto doses next month. PSA has decreased some. SE have been much easier to tolerate than chemotherapy. What is the recommended maintenance treatment after receiving Pluvicto?

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larke | @larke | Jul 15, 2024
In reply to @lag "larke, I am happy to hear that there are clinical trials for men who could benefit..." + (show)
@lag

larke, I am happy to hear that there are clinical trials for men who could benefit for more than six Pluvicto infusions. My husband is already worrying about what comes after his sixth infusion in August.

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This is somewhat on the experimental side. IF good reaction (much lower PSA) and still functional, UPennMedicine is trying this. Seems logical. Delay from March ‘til now for me to recover from cumulative effects of radiation.
I’m 85.
Luck .

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smc24 | @smc24 | Aug 10, 2024
In reply to @gaherrma "Wanting to know what doctors are telling patients about what is course of action after first..." + (show)
@gaherrma

Wanting to know what doctors are telling patients about what is course of action after first six pluvicto treatments?

Can Pluvicto be repeated?
Has it been in EU where it was approved longer ago?

Gina

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Did anyone every answer the question, can Pluvicto can be repeated after the initial 6 treatments? Quesses and opinions don't count.

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1 reply
melcanada | @melcanada | Aug 11, 2024
In reply to @melcanada "Did 6 injection Xofigo feel great diarrhea some days getting CT as we speak tomorrow bone..." + (show)
@melcanada

Did 6 injection Xofigo feel great diarrhea some days getting CT as we speak tomorrow bone scan

Precious blood of Jesus heal me daily

What is next psa 31.4

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PSA now 41 1 Looking at chemo Mets still in bones only T 5 L! S! and 9th left rib

help

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rxharleydude | @rxharleydude | Aug 12, 2024
In reply to @larke "No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to..." + (show)
@larke

No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to 8. March 13 completed.
Agreed to be a test case for MORE Pluvicto and will likely begin in early August. Likely two or three applications.
Larke

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Can you tell me who is heading up the “extra Pluvicto dose” study? I am currently on Pluvicto and will be facing the same issue of “where do we go next” when I finish the six dose regimen. It would be great for my medical team to follow the results of that study!

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smc24 | @smc24 | Aug 15, 2024
In reply to @larke "No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to..." + (show)
@larke

No initial delay. Completed the usual 6 treatments, six weeks apart. Relative success: PSA 75 to 8. March 13 completed.
Agreed to be a test case for MORE Pluvicto and will likely begin in early August. Likely two or three applications.
Larke

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Large, where are you receiving the 2nd round of Pluvicto treatments?

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1 reply
kbrz | @kbrz | Aug 16, 2024
In reply to @lag "larke, I am happy to hear that there are clinical trials for men who could benefit..." + (show)
@lag

larke, I am happy to hear that there are clinical trials for men who could benefit for more than six Pluvicto infusions. My husband is already worrying about what comes after his sixth infusion in August.

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Completed Pluvicto #6 July 16 and am happy to hear the
possibility of additional treatments if needed. PET scan Sept 04 then a sit down with my Doctors to decide next move.

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round5 | @round5 | Aug 16, 2024

Lupron and Nubeqa for me. They mentioned something about 2 years of it. I’ll find out more when I go back in September And have my scan.. I completed my 6th.dose in April. I went straight from chemotherapy to Pluvicto so I was already on the two drugs mentioned above when I started pluvicto.

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lag | @lag | Aug 16, 2024
In reply to @smc24 "Large, where are you receiving the 2nd round of Pluvicto treatments?" + (show)
@smc24

Large, where are you receiving the 2nd round of Pluvicto treatments?

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Larke posted above that it is at UPenn Medicine.

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lag | @lag | Aug 16, 2024
In reply to @smc24 "Did anyone every answer the question, can Pluvicto can be repeated after the initial 6 treatments?..." + (show)
@smc24

Did anyone every answer the question, can Pluvicto can be repeated after the initial 6 treatments? Quesses and opinions don't count.

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The FDA has only approved six treatments of Pluvicto, so that is all men can receive in the US. A few US sites are doing clinical trials of extra Pluvicto infusions. (I learned on Wednesday, August 14, that Mayo Rochester is not one of them. We asked during an appointment with Dr. Kwon, and got the same answer later that day from the Nuclear Medicine providers giving my husband his sixth Pluvicto infusion.)

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1 reply
smc24 | @smc24 | Aug 28, 2024
In reply to @lag "The FDA has only approved six treatments of Pluvicto, so that is all men can receive..." + (show)
@lag

The FDA has only approved six treatments of Pluvicto, so that is all men can receive in the US. A few US sites are doing clinical trials of extra Pluvicto infusions. (I learned on Wednesday, August 14, that Mayo Rochester is not one of them. We asked during an appointment with Dr. Kwon, and got the same answer later that day from the Nuclear Medicine providers giving my husband his sixth Pluvicto infusion.)

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I finished 6 rounds of the original clinical trial Lu177 PSMA-617 in 2022 with remarkable results. It was approved in the US a few months later as Pluvicto. Now, I will be one of the first patients to repeat the same 6 treatments, starting Sept. 3, 2024. Going into unknown territory, again. Beats dying without trying.

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