I take 500 mg of hyroxyurea 5 days a week, and 1000 mg of hydroxyurea on Monday and Friday. My legs do ache due to the hydroyurea. The one thing that makes my leg pain go away is me riding the exercise bike we have. All I can figure out is that hydroxyurea has a tendency to settle in places and stay in those places and cause pain. Once the blood starts flowing again, due to exercising using the exercise bike, the pain in my legs goes away. Drinking a lot of water is a bit of help to keep things moving but the exercise bike really creates good blood flow and the aching goes away for the entire day and evening.

I do hope as time goes by, your pain goes away or lessons.

It is best to take hydroxyurea before bed, for me anyway, so that I am not clumsy and bumping into walls during the day.

It is the weirdest medication I have taken. Wishing you well.