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Hi Tom, I'm 70 and have been on Orgovyx + Abiraterone for about three months. I had to fight to get Orgovyx because my oncologist wasn't aware of the STAMPEDE trial. Once he read it, he prescribed it for me with the warning that it was a new drug, it was expensive, and we still don't know what happens after being on it for n+ years.
The combination works great, and I recommend it highly. However, the side effects for me have been difficult to deal with. These include periods of hot flashes that come and go every few hours, even while I'm asleep. And I'm constantly fatigued. Ironically, the best solution for my fatigue is exercise. I row at least 30 minutes a day, four days a week. I use a TRX system for strength-training four days a week. And I take an online Pilates class three days a week. All of the above is done at home.
Best of luck as your treatments continue.
Jeff
Replies to "Hi Tom, I'm 70 and have been on Orgovyx + Abiraterone for about three months. I..."
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Just to clarify, the arm of the STAMPEDE trial I was referring to was testing the effect of adding abiraterone to basic ADT with or without radiotherapy. The report I saw did not distinguish what type(s) of basic ADT were used, though given the timeframe during which patients were randomized, Orgovyx was not yet commercially available. What's more, I don't think it would make any difference in the outcomes because Lupron et al and Orgovyx/Firmagon do essentially the same thing, shut down the testes. The latter just do it more quickly and don't have a T spike.
He's correct it's. anew drug and long term side effects may not be well understood, but it's method of action is like Firmagon/Degarelix which has been in use since 2008.
So, that arm of the STAMPEDE would not have been testing the efficacy of Orgovyx. That was done in the original clinical trial for Orgovyx - HERO.