Hi I will be 61 soon and have battled depression and anxiety most of my life. Been hospitalized and through many treatments and had been taking effexor since 2007. I had been telling my doctors that my meds aren’t working and they kept adding a supplement such as welbutrin and abilify, they didn’t help either and the doctors kept having me try them numerous times. Finally became dissociative and went inpatient to a fabulous place. I asked to have my gene site test repeated due to advances in dna. So glad I did! Found out I have a gene mutation MTHFR homozygous, meaning I got the mutation from both parents. Plus the variant I have is more rare. What this means is my body was not able to absorb the medications. Went to integrated behavioral health at Mayo and the doctor did lots of bloodwork and he also had me test for pyrole disorder. Came back that I have that too. I’m now being treated with vitamin supplements and not on any antidepressants or anti anxiety medications. I have done a 180 and feel great. I have only been on the vitamins for about 1 month. I strongly encourage you to have this test done. Make sure your insurance covers it. It’s an expensive test. I only had to pay $300 of the $5000 plus charge and the pyrole test was $130.