I'm in a research study right now that is trying to stop Myeloma in its tracks. I was diagnosed with MGUS in 2022. I just started this study protocol in May, and glad I did because a new bone marrow biopsy showed I had progressed to SM. For the first 3 months of the study, I took a curcumin-bioperine supplement or a placebo (I don't know which) of 1000mg twice daily. I take it with a combination of fats to aid the absorption. After a month of being on the supplements, my numbers dipped slightly, but now after 3 months, they have gone back up to about what they were before the supplement. My research doc says it is probably just a normal variation. Today, I started the 2nd phase by switching to a whole-foods, plant-based diet. The study has been done before without the supplements and had very promising results. This part of the study for me runs at least through April 2025. I joined the study because like you, I didn't want to sit around and wait for progression. I also didn't want to take any more drugs, as I've struggled with a variety of health problems over the past few years and the "cures" were worse than the "disease" although it did lead to my initial MGUS diagnosis. I've been doing much better since I stopped taking the medications and I'd like to keep it that way.