My hemo followed the same plan when I went on HU 6 years ago. I am 70, CALR+, same dosage as you.

My platelets run between 425 and 475, and doc considers this "very stable." She isn't anxious to add more HU because CALRs seem to have fewer clotting episodes, and my other stroke factors are low ( low cholesterol levels, on aspirin, well controlled hypertension).

So lesson learned: We are all different, and treatment goals and dosages are more likely to be adjusted to the individual. And that's really a good change from 25 ago, when my dad was diagnosed with ET.

I do think that ET exacerbates the effects of aging. When I compare myself to my friends (which I try NOT to do), I seem to have less energy and general stamina, and more frequent nuisance-type problems (dizziness, headaches, skin and hair dryness and irritation, brain fog). In older age, though, I have a better mental attitude, and I can push through the nuisances better than when I was younger. So there's that.