Hi ladies! I am 52 and was diagnosed in 2022 with E.T. and after my bone marrow biopsy, I do have the Jack2 mutation. I have been on Hydroxurea for almost 2 years and have had no side effects. I now go every 3 months for lab/blood work....the first year I went every month and only took 1 (500mg) of Hydroxy to see how my body would handle it (in 2022 when diagnosed, my platelets were over 850) and after about 6 months, my platelets were not dropping as much as expected (in the 700 range), so she added 2 (1000 mg) once a week and 1 (500 mg) the rest of the week for 5 more months (stayed in the 650 range). My platelets dropped gradually, so she added 2 (1000 mg) twice a week and 1 (500 mg) the rest of the week for another 6 months and platelets were still higher than expected, but she was making sure adding the dosage was not affecting my body, since it has not, (thankfully), I am now on 2 (1000 mg) 3 x a week with 1 (500 mg) dosage the rest of the week and I am now going every 3 months for labs/Dr visit and my platelets are now in the high 400 range, which is amazing! We are still trying to get them in the 200-400 norm range, but considering I am almost there with this dosage of Hydroxy, I am thankful and blessed. This will be a lifelong med for me, and she may have to adjust every so often how much, depending on how my body is responding to the dosage (like blood pressure meds and those types of meds you have to be monitored because it fluctuates like our platelets), but at least I know that I am as safe as I can be as far as my blood goes, from having a heart attack, stroke or blood clots with Hydroxy! It certainly is a very scary situation to have your body (blood) deceive you in such a way, but thank goodness for our medical professionals and current data that we have these amazing people helping us and guiding us and our bodies to help us on our journey!