Oh, yes that must be worrisome. Waiting is really hard. When will you have the tests done?

Hello Colleen. I have a question for you and Jim. First I will comment on the bradycardia because it has been an increasing issue with me. I have been treated for hypothyroid for over 30 years. My low heart rate has gotten lower, especially when I sleep (45 to 50 bpm), making getting out of bed in the morning a process. TSH is normal with the synthroid supplement. I take a supplement to successfully increase my B-12 levels as they were barely within normal, but my extreme fatigue is a major problem still. My testing has produced low cortisol levels. Imaging has shown no thoracic or pelvic tumors. My family history is positive for 3 generations of pituitary adenoma, and adrenal failure NOS and resulting in death. The deaths occurred before diagnosis/treatment options existed. Do you know of websites with good information on secondary adrenal dysfunction? I have researched quite a bit already, including some of the excellent Mayo sites. There must be research happening which I have not been able to access yet, especially including the familial connection. I think I have already had 2 big cortisol crashes following surgeries, but I was in lucky locations each time. I am undiagnosed at this point, but it is in process. I have 4 daughters, two of whom have significant disruptions (including a cystic like tumor removed on one.) I want o get information for them, and I want to see my future grand kids. Any validated studies will be appreciated. Thanks!

Great questions Upartist, which are out of my scope of knowledge. But I'm tagging @johnwburns, @jmbjar and @predictable to see if they can help sleuth validated studies with you.

Thank you so much Colleen! I appreciate it. Information (real information) helps me understand the process, so I can fend off the dominoes.