Again, I am so sorry about your reaction! It does make me nervous to know that this can happen, so I have to decide which is the worst of the two evils...taking the chance on Iovera (I, personally, have heard of so many personal positive reviews of Iovera and even told my pain management about it, and he is now in training for it since there are very few who do it here in California) or going through the horrible pain of the recovery of the TKR itself. I have lost weight, do exercises to strengthen my thigh muscles every night, and stretch daily. That alone has helped my pain go way down (that and cortisone injections) so I am still in the 'holding' phase of this..But I have to say I have heard so many positive reviews of Iovera, too, so it's hard to know what to think and/or decide...