Connect
← Return to MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio
Discussion
MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio
Blood Cancers & Disorders | Last Active: Aug 3 1:59pm | Replies (203)Comment receiving replies
I have had 2 organ transplants the past 25 years and pheriferial neuropathy in both feet and ankles. I asked my Neurologist why the neuropathy, and they did more testing and found my kappa lightchain high, my lamda lightchain is normal and the M protein was zero.
Replies to "I have had 2 organ transplants the past 25 years and pheriferial neuropathy in both feet..."
Connect
I have had MGUS and polyneuropathy for around 8 years, mostly minor loss of feeling and pain. My Kappa is 283 mg/L and Kappa/Lambda is about 20, M is at detection limit. The Kappa proteins can glom onto neurons and decrease their activity, thereby resulting in neuropathy (a lay person's explanation anyway). I use my hands a lot and the neuropathy hasn't progressed. Neuropathy can be caused by other things as well, diabetes being a primary one. I have celiac disease, which may also impact neuropathy. Here is some info: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604635/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573223/