I've responded to a similar inquires re PPI use and the development of peripheral neuropathies from members of the esophageal cancer forum. However, I am posting this recent publication in this month's edition of the scientific journal, Nature.
Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory
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Published: 21 November 2019
Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory
Tigran Makunts, Sama Alpatty, Kelly C. Lee, Rabia S. Atayee & Ruben Abagyan
Scientific Reports volume 9, Article number: 17280 (2019) Cite this article
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Abstract
Proton-pump inhibitors, PPIs, are considered effective therapy for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump in the gastric parietal cells. They are widely prescribed and are considered safe for over-the-counter use. Recent studies have shown an association between PPI use and Alzheimer dementia, while others have disputed that connection. We analyzed over ten million United States Food and Drug Administration Adverse Event Reporting System reports, including over forty thousand reports containing PPIs, and provided evidence of increased propensity for memory impairment among PPI reports when compared to histamine-2 receptor antagonist control group. Furthermore, we found significant associations of PPI use with a wide range of neurological adverse reactions including, migraine, several peripheral neuropathies, and visual and auditory neurosensory abnormalities.
@davidwrenn
WOW I've just read this study. It almost 6 years old and shocking these PPIs are STILL being given out like sweets. I had 2 gut surgeries in 2024 and both times told had to take PPIs for 8 weeks afterwards.
I developed numbness first on right foot then month or 2 later also left foot. Now 6 months after my last surgery and 3 months after ending PPIs I'm stuck with very painful burning in feet and wrists and side hands . Been diagnosed with Small Fibre Neuropathy (SFN) which is a sensory axonal neuropathy. No reason except "probably idiopathic --- detest that word.
I'd be most interest to know if anyone else has heard of others suffering the same fate after taking PPI's (:
If we can find these medical articles why on earth can't the doctors and surgeons recommending these drugs at least warn us of these risks (:
Please please let me know if you find other studies or if anyone else is affected please let me know.
Regards
Linda Cameron