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Orgovyx and Zytiga combined

Prostate Cancer | Last Active: Aug 13 9:21am | Replies (37)

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@russ777

I'm not sure if your onco is saying there are no studies on Orgovyx+abiraterone, or Lupron+abiraterone, but it should not matter. All of these patients being put on ADT + abiraterone/Zytiga with high risk localized or locally advanced disease are doing so based on the STAMPEDE trial that has been ongoing in the UK and Switzerland. One of the many trials included under STAMPEDE was for patients with high risk, non-metastatic disease. It did include patients with locally advanced disease , i.e., pelvic nodes. The latest reporting I saw was at 108 months from start of treatment PCa-specific survival was 85-ish% for the arm in which patients took abiraterone in addition to ADT and high 60's% in the arm with ADT only. That is a huge benefit and is what caused the standards bodies to designate this combination therapy for high risk, non-metastatic patients as Standard of Care. There was no distinction made by the type of ADT used in both arms, so Lupron versus Orgovyx should be a non-issue.

So I would press your doctor to show you proof there is no evidence of that combination being used. It has been Standard of Care for some time now. Mention the STAMPEDE trial.

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Replies to "I'm not sure if your onco is saying there are no studies on Orgovyx+abiraterone, or Lupron+abiraterone,..."

My oncologist agreed to put me on ORGOVYX along with Abiraterone. He’s a brilliant doc and I like him and respect him. His biggest concern was the out of pocket cost for Orgovyx since I need to be on ADT for 2 years. I qualified for financial assistance so cost is not an issue but based on how well I feel, I would’ve figured out how to pay for it if I had to.

I’m doing great; arguably better (less side effects) than my cohorts that are taking Lupron and Abiraterone. My PSA drop like a rock in only three weeks and became undetectable and still is undetectable. My oncologist is delighted.

All the best to you for success on your journey!