Hi, @jackie421blfdgurl. It is good to hear from you!
I'm sorry to read that you had a reaction when you were taking sirolimus once before. I can understand your nervousness. However, it sounds like your liver doctor has a plan to monitor your labs every week so that she can carefully monitor the level and monitor your liver enzymes and any side effects (like the mouth sores). It will be your responsibility to contact her right away if those side effects appear. That way the dose could be adjusted before any problem occurs. She is aware of your previous reaction, isn't she?
Jackie, Sirolimus is a good medication - that is why so many transplant patients are taking it. Each one of us reacts differently to the meds and our transplant doctors are going to work to find the one that works best for each one of us. I think it is a good thing that she is carefully watching the blood pressure meds since she suspects it is causing your swelling.

I want to re-connect you with a discussion where you joined toward the end of the conversion. If you have not already done so, Please look at what others have shared about sirolimus from their experience.
- Do any transplant patients here have experience with Sirolimus?
https://connect.mayoclinic.org/discussion/do-any-transplant-patients-here-have-experience-with-sirolimus/
@gratefulbob, @charlie5454s, @cehunt57, Do you have any experience with Sirolimus that you would share with @jackie421blfdgurl?