Erleada and Lupron: Does this combo wipe anyone else out?

Another analogy. We all want to reach an undetectable PSA and clear PSMA scan with no further therapy. That is the destination. You are the captain of the ship so you decide the route to reaching your destination, i.e. the course of therapy. The doctors are the navigators who tell you the pros of cons of the possible routes to your destination. Then you decide on the route.

I worked in the deserts of the Middle East for many years and consider a siesta one of the great inventions of the world. Have lunch, let it digest, sleep, and wake up most refreshed.

Finished 6 injections of Radium 223 PSA still 31.4 No mets outside spine bones Feel great but oncology wants chemo?

On zolodex Xgeva calcium 600 d + k

Yep, living it now on Eligard. What all side effects other than these mentioned are you guys
noticing?? For me, achy all over, brain fog at times, extreme fatigue, yes, hot flashes, just a weird
feeling at times, cholesterol increased.

Pushing through might not work, because it could knock you right into bed before you see any benefits. It's more a matter of bootstrapping: make a lot of little choices every day, instead of sweating it out forcing yourself to do hour-long exercise sessions. Eventually, they start to pay off, and you have a little more energy that you can use to get a little more active, then being a little more active gives you a little more energy, etc. in a virtuous circle.

Some examples of little choices:

1. Park your car a little further from the store.
2. Get off the bus or subway one stop earlier.
3. Walk to the corner store to get milk.
4. Curl some very light dumbbells while you're watching TV.
5. Stand up from a chair sometimes without using your arms to push.

Etc. Even with baby steps like that, you'll have setbacks, but eventually (I hope) you'll see a positive improvement over time. Working with a physiotherapist, rather than taking advice from random online strangers like me, would also be a good idea. 😉

I m on Trelstar it’s just like Lupron. Feel wiped out a lot, naps help me. In the am, I get up, 3 hours later I m whipped so I lie down for awhile. ASSAM tea from Amazon gets me going. Anti cancer tea. Tastes malty. Don’t take it after 6 pm, you won’t sleep. There ya go. Take care. Watching PRICE IS RIGHT is my rest time. Lol

You know, I already do a lot of that - take two steps at a time, take stairs instead of elevator, etc. I have not experienced hormones to date - waiting (and waiting!) for my consult appt at Sloan. I highly doubt they’ll say I don’t need them - even though PSA is only .18 5 yrs post surgery…they are very traditional and don’t rush in to change protocols quickly.
I’ve already found an RO who said that I don’t need hormones based on new research, but I’m on the fence as to whether this is true in all cases ( NO Decipher Test unfortunately).

I don't remember your stage, but there's good evidence emerging that "treatment holidays" — stopping ADT and ARSI and waiting to see if your PSA starts rising again — produce overall-survival outcomes that are as good or slightly better for EARLIER STAGE prostate cancer.

Last I read, the evidence still showed slightly worse outcomes after treatment holidays for stage 4, but I'm still hopeful that will change when they've collected more data.

You're the CEO of your treatment team, so after hearing advice, it's your final decision what to do. I opted against a treatment holiday because I'm stage 4b oligometastatic and tolerating the hormone treatment well, but I may change my mind when a the results of a few more studies are in.

(I should add that it's not just about fighting the cancer: according to the lengthy drug-manufacturer brochures they give us at the pharmacy, ADT and ARSI can increase the risk of other dangerous conditions like heart disease, obesity/diabetes, and osteoporosis, so even if a treatment holiday slightly increases the risk of your cancer coming back as castrate-resistant, you and your treatment team might decide that's a smaller danger for you, personally, than elevated risk of a heart attack.)

I am wondering if ADT has serious side effects affecting our bone structure. This past February I suffered from compression fractures in 3 vertebrae. I am going in next week for my right hip replacement surgery. My insurance company will not pay. The reason given is ‘pre existing condition’. I now have osteoporosis and arthritis. Has anyone had a similar experience?My oncologist says due to adverse hormonal effects it may very well mean that while ADT is helping with the cancer it is causing bone damage. I just started takin Prolia. I hope it helps.

I have stage 4 metastasis in the bones, I was on Xgeva for one year and recently I started getting the shot quarterly. Suppose to help strengthen the bones, plus taking lots of calcium. Of course listen to your doctor, only saying what they they me on. Best to all.