Hi. I started Camzyos last October after having HCOM for over 5 years. I recently became more symptomatic (65 y/o), having trouble climbing stairs without SOB at the same time my ECHO showed a significant increase in my gradient (over 100). I elected to start Camzyos and had an immediate decrease in my gradient to normal. HOWEVER, I did not feel much different. Since I had minimal side effects, I stayed on the medication. After 6 months my Cardiologist surprisingly stated he could barely hear my murmur anymore! We feel this is related to my mitral valve flap or septum decreasing in size. I am now trying to push myself to attempt more stairs and get my exercise tolerance back up to speed. Fingers crossed. I am grateful I persisted with staying on the medication and hope everyone would give it a year to assess benefits.