Erleada and Lupron: Does this combo wipe anyone else out?

Being on Arbiterone/ prednisone too, plus a Trelstar butt shot every 3 months: I conquer fatigue via an hour nap daily, when I wake up I feel almost normal.

I had a similar issue with urgency and (sometimes) incontinence last summer due to minor lower-bladder damage from radiation the year before.

My main oncologist referred me to an oncology urologist, who agreed that it didn't make sense for me to be on Flomax when I had no trouble urinating (just the opposite). Instead, he switched me to Myrbetriq, which relaxes the detrusor muscle on top of the bladder and reduces the frequency and urgency of bathroom trips.

Another suggestion is to keep a urinal bottle by the side of the bed so that you don't have to run to the bathroom every time you wake up. I'd had to do that when I was in a wheelchair, so I had a couple left over.

I started out with casodex 2021.The side effects hard to get used to.Then I was on firmagon and erleada .I would self inject and take 240mg erleada.After my visit to the Mayo my erleada was halved to 120mg.This helped with my lethargy and terrible constipation.Presently I’m on 120mg erleda which I take before bedtime.I get lupron injections every 4 months.I try and take a nap after lunch.I do my morning walk and physio exercises.I’m pretty good until after 5 or so.Then when I settle down to read or watch a little tv or so that’s when ‘rigor mortis’ sets in for the rest of my day.Getting up from the couch starts a cascade of pain.My spine,my legs and neck make it hard to get up and go up the stairs to get ready to sleep.I sleep well and this cycle repeats itself daily.My psa is .02 and I’m happy to be alive.There are and will be new drugs for which we will benefit .Perhaps,one day,there will be a cure.I think optimism is part of that cure.

"optimism is part of the cure"

100%. Also, relentless curiosity — keep asking questions and taking notes, so that your treatment is something you're involved in, rather than something that just happens to you.

There's no room for passengers in prostate-cancer treatment — if physically and mentally able, we have to be active members of our care teams.

This topic always confuses me, the part about taking part in the treatment. My job is to take my shots and meds and go for my visit. I have high school diploma but I'm figuring the treatment center has smarter people. they offered to lower my dose of chemo when I mentioned kicking my butt, I chose not to because I was more concerned with the cancer. they offered to cut down on prednisone but again I wanted the recommended dose. I learn alot on here but to be honest I also get lost a lot of times. Northoftheborder, you inspire me and give me hope to better days ahead. I hope this post doesn't start a firestorm, just want to say we are all doing the best we can. Best to all.

That’s an expected side-effect. Lupron (an ADT) suppresses testosterone - which will result in fatigue; Erleada (apalutimide; an ARPI) interferes with the androgen receptor pathways - which will result in fatigue. Unless you’re doing something to minimize those side-effects, they will continue.

What can minimize them? I know exercise is important but if the meds wipe you out how do you manage?
I guess you just have to mentally push through it like most hardships.

Because the vigorous resistance-training is supposed to start well before you start the meds. That way you’re working to maintain the lean muscle mass before the hormone therapy wipes you out.

Here’s a video from a recent PCRI conference about hormone therapy and the physical benefits of exercise:
> https://m.youtube.com/watch?v=YE61HSAsFb0